Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13068587 | 0.75 | MAPT (0.48) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL11621872 | 0.75 | GAA (0.48) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL11619520 | 0.75 | GAA (0.48) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL826206 | 0.74 | — | — | |
| Bromide SCHEMBL11620749 | 0.73 | GAA (0.46) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL30513887 | 0.72 | ACVR1 (0.52) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL1572195 | 0.71 | MAPT (0.43) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL11486708 | 0.71 | GPR84 (0.50) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL29926234 | 0.71 | MAPT (0.43) | MAPTGAAPDGFRAFERLTK | |
| SCHEMBL11115946 | 0.71 | GAA (0.43) | MAPTGAAPDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235895-A | FOR TREATING EPILEPSY | CIBA-GEIGY CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0011603-A1 | 10-Nitrilo-5H-dibenz(b,f)azepine-5-carboxamide, process for its preparation and pharmaceutical compositions containing it | CIBA-GEIGY AG (CH) | 1980-05-28 | — | — | EP | disclosed |
| US-4076812-A | 10-Halogeno- or 10,11-dihalogeno derivatives of 5H-dibenz[b,f]azepine | CIBA-GEIGY CORPORATION (US) | 1978-02-28 | — | — | US | disclosed |