Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042983 | 0.91 | LMNA (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL8481498 | 0.91 | LMNA (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8486883 | 0.90 | LMNA (0.66) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1038937 | 0.90 | LMNA (0.66) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1037717 | 0.89 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1038890 | 0.89 | LMNA (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1041457 | 0.89 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1039145 | 0.89 | LMNA (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1042520 | 0.89 | LMNA (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1042773 | 0.89 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2660238-B1 | Compounds for the prevention and treatment of cardiovascular disease | RESVERLOGIX CORP (CA) | 2015-05-06 | — | — | EP | disclosed |
| EP-2382194-B1 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE | RESVERLOGIX CORP (CA) | 2014-03-12 | — | — | EP | disclosed |
| US-4183931-A | SEDATIVE-HYPNOTICS, ANTICONVULSANTS, CENTRAL NERVOUS SYSTEM DEPRESSANTS | RESEARCH CORPORATION (US) | 1980-01-15 | — | — | US | disclosed |