SCHEMBL11501150

SCHEMBL11501150

CCc1cccc(C)c1N[C@@H](C)C(=O)O.NCC(=O)OCc1ccc(Cl)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.46
HTT P42858 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
GALR3 O60755 1/20 0.39
CYP3A4 P08684 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
S1PR4 O95977 1/20 0.39
NLRP3 Q96P20 1/20 0.38
HDAC8 Q9BY41 3/20 0.37
HDAC6 Q9UBN7 1/20 0.37
KMT2A Q03164 2/20 0.37
NR4A1 P22736 1/20 0.37
NR4A2 P43354 1/20 0.37
NR4A3 Q92570 1/20 0.37
MRGPRX4 Q96LA9 2/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
ATM Q13315 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PTGER1 P34995 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11501383 0.94 GAA (0.49) GAAHTTCYP1A2CYP2C19GALR3
Glycine SCHEMBL11341764 0.89 GAA (0.53) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11336709 0.86 GAA (0.59) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11336691 0.86 GAA (0.59) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11274955 0.83 NLRP3 (0.42) HTTSMN1; SMN2NLRP3L3MBTL1TDP1
Glycine SCHEMBL11337199 0.82 GAA (0.57) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11501437 0.81 NLRP3 (0.42) GAAHTTSMN1; SMN2NLRP3KMT2A
SCHEMBL11348208 0.79 GAA (0.64) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11348210 0.79 GAA (0.64) GAAHTTCYP1A2CYP2C19GALR3
SCHEMBL11498543 0.79 NLRP3 (0.40) GAAHTTSMN1; SMN2NLRP3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0009569-A1 Oxalyl derivatives of N-phenylaminocarboxylic acids (and their esters), processes for their preparation and their use as fungicides BAYER AG (DE) 1980-04-16 EP disclosed