Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11460061 | 0.81 | CA1 (0.42) | HTTKMT2AALOX12LMNAALDH1A1 | |
| SCHEMBL11459213 | 0.77 | NR1I2 (0.41) | KMT2AALOX12ALDH1A1GAATRPM5 | |
| SCHEMBL6510724 | 0.76 | OPRK1 (0.46) | KMT2ABRD4LMNAGAACHEK1 | |
| SCHEMBL11287985 | 0.75 | TRPM5 (0.42) | KMT2ABRD4LMNACHEK1AURKA | |
| SCHEMBL11284457 | 0.75 | TRPM5 (0.42) | KMT2ABRD4LMNACHEK1AURKA | |
| SCHEMBL11281221 | 0.75 | TRPM5 (0.42) | KMT2ABRD4LMNACHEK1AURKA | |
| SCHEMBL11679438 | 0.72 | PRCP (0.41) | KMT2AALOX12ALDH1A1GAATRPM5 | |
| SCHEMBL1623976 | 0.71 | TRPM5 (0.41) | KMT2ABRD4LMNATRPM5TRPM4 | |
| SCHEMBL11434287 | 0.71 | BRD4 (0.42) | BRD4LMNASMN1; SMN2TRPM5TRPM4 | |
| SCHEMBL8188946 | 0.70 | TRPM5 (0.42) | KMT2AALOX12LMNAALDH1A1TRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228167-A | Diuretic and vasodilating tricyclic quinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-10-14 | — | — | US | disclosed |