Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.51 |
| ▸ | FEN1 | P39748 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697056 | 0.89 | MAPT (0.57) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL31414407 | 0.81 | MAPT (0.63) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL10001233 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL8534233 | 0.81 | SMN1; SMN2 (0.84) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL16998568 | 0.79 | MAPT (0.53) | L3MBTL1HPGDLMNARAB9AMAPT | |
| SCHEMBL3733726 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL28394787 | 0.79 | HSD17B3 (0.62) | L3MBTL1RAB9AMAPTPTPN1ALDH1A1 | |
| SCHEMBL20135180 | 0.79 | KMT2A (0.60) | SMN1; SMN2LMNARAB9AMAPTGSK3B | |
| SCHEMBL28460581 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A | |
| SCHEMBL10986985 | 0.78 | HDAC1 (0.63) | SMN1; SMN2L3MBTL1HPGDLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136200-A | PHENYLBUTANOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-01-23 | — | — | US | disclosed |
| US-4049823-A | Phenylbutanol derivatives and compositions containing them | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-20 | — | — | US | disclosed |