Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.37 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.37 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 4/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11506946 | 0.89 | PDE2A (0.42) | — | |
| SCHEMBL11509314 | 0.86 | KCNK3 (0.40) | SLC2A1SLC2A2SLC2A3SLC2A4KCNK3 | |
| SCHEMBL11509317 | 0.85 | EGLN1 (0.36) | ALDH1A1HTT | |
| SCHEMBL11509157 | 0.84 | LMNA (0.40) | KCNK3ALDH1A1MAPTCLK1 | |
| SCHEMBL11507511 | 0.84 | GPR139 (0.35) | — | |
| SCHEMBL11508687 | 0.77 | KDM5A (0.37) | KCNK3CLK1DYRK1A | |
| SCHEMBL11612817 | 0.77 | HSD17B10 (0.38) | ALDH1A1MAPTHTTP2RY1 | |
| SCHEMBL11508068 | 0.74 | AKR1C3 (0.40) | KCNK3ALDH1A1CLK1DYRK1A | |
| SCHEMBL11507530 | 0.74 | PTGS1 (0.36) | ALDH1A1HTT | |
| SCHEMBL11509147 | 0.73 | GPR139 (0.36) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160098-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-03 | — | — | US | disclosed |
| US-4122281-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122279-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122280-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4096152-A | DIURETICS, SALURETICS, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-4069334-A | DIURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4002641-A | DIURETICS, SALURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | disclosed |