Sugi Predict

Sugi Predict / Compounds / SCHEMBL1150765

SCHEMBL1150765

SCHEMBL1150765

COC(=O)c1nc2n(CC(=O)N3CC(C)CC(C)C3)cc(CSC)n2c(=O)c1O

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KDM4E B2RXH2 4/20 0.34
▸ LMNA P02545 2/20 0.32
▸ MAPT P10636 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ RECQL P46063 1/20 0.32
▸ GAA P10253 2/20 0.31
▸ GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12862284 0.87 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL1151034 0.79 KDM4E (0.40) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL12862232 0.79 KDM4E (0.40) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL1150433 0.76 KCNH2 (0.34) ALDH1A1KMT2AMEN1KDM4ETSHR
SCHEMBL1150820 0.69 KDM4E (0.38) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL12862231 0.69 KDM4E (0.38) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL12875079 0.67 KDM4E (0.36) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL1150761 0.65 KDM4E (0.40) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL1150834 0.64 L3MBTL1 (0.43) ALDH1A1SMN1; SMN2KMT2AKDM4ELMNA
SCHEMBL13522398 0.64 POLB (0.35) ALDH1A1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2291377-B1 IMIDAZOPYRIMIDINONES AND USES THEREOF AVEXA LTD (AU) 2015-02-18 — — EP disclosed
EP-2291377-B1 IMIDAZOPYRIMIDINONES AND USES THEREOF AVEXA LTD (AU) 2015-02-18 — — EP disclosed
US-8431581-B2 Imidazopyrimidines and uses thereof AVEXA LIMITED (AU) 2013-04-30 — — US disclosed
US-8431581-B2 Imidazopyrimidines and uses thereof AVEXA LIMITED (AU) 2013-04-30 — — US disclosed
US-8431581-B2 Imidazopyrimidines and uses thereof AVEXA LIMITED (AU) 2013-04-30 — — US disclosed
EP-2291377-A1 IMIDAZOPYRIMIDINONES AND USES THEREOF Avexa Limited (AU) 2011-03-09 — — EP disclosed
US-20110028487-A1 IMIDAZOPYRIMIDINES AND USES THEREOF AVEXA LIMITED (AU) 2011-02-03 — — US disclosed
US-20110028487-A1 IMIDAZOPYRIMIDINES AND USES THEREOF AVEXA LIMITED (AU) 2011-02-03 — — US disclosed
US-20110028487-A1 IMIDAZOPYRIMIDINES AND USES THEREOF AVEXA LIMITED (AU) 2011-02-03 — — US disclosed
WO-2010000031-A1 IMIDAZOPYRIMIDINONES AND USES THEREOF AVEXA LIMITED (AU) 2010-01-07 — — WO disclosed
WO-2010000031-A1 IMIDAZOPYRIMIDINONES AND USES THEREOF AVEXA LIMITED (AU) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110028487-A1 IMIDAZOPYRIMIDINES AND USES THEREOF TPMT, DPYD, IMPDH1 ALDH1A1 205/4885SMN1; SMN2 958/4885KMT2A 1900/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.