Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508181 | 0.88 | PTGDR2 (0.38) | PTGDR2SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL11454347 | 0.86 | MAP3K14 (0.41) | PTGDR2SMN1; SMN2GPR139GCGRCYP26A1 | |
| SCHEMBL11507240 | 0.84 | PDE2A (0.37) | PTGDR2SLC6A3ALDH1A1LMNAHTT | |
| SCHEMBL11507274 | 0.82 | SLC6A3 (0.38) | PTGDR2SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL11507201 | 0.82 | PTGS1 (0.36) | PTGDR2SLC6A3ALDH1A1LMNAHTT | |
| SCHEMBL11507802 | 0.82 | AKT1 (0.34) | PTGDR2PTGS1GPR139MAP3K14EGLN1 | |
| SCHEMBL11509039 | 0.80 | GPR139 (0.37) | SLC6A3SLC6A2SLC6A4LMNAGPR139 | |
| SCHEMBL11509135 | 0.80 | KMT2A (0.41) | PTGDR2ALDH1A1HTTGPR139CYP26A1 | |
| SCHEMBL11559647 | 0.80 | GPR139 (0.34) | PTGDR2PTGS1GPR139MAP3K14EGLN1 | |
| SCHEMBL11507538 | 0.80 | MAPT (0.39) | PTGDR2SLC6A3SLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160098-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-03 | — | — | US | disclosed |
| US-4122281-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122280-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122279-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4096152-A | DIURETICS, SALURETICS, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-4069334-A | DIURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4002641-A | DIURETICS, SALURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | disclosed |