Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 4/20 | 0.60 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839222 | 0.86 | SRD5A2 (0.58) | MAPTRAB9AMAOBTNKSPARP15 | |
| SCHEMBL5519221 | 0.85 | SRD5A2 (0.61) | MAPTTNKSPARP15PARP14PARP10 | |
| SCHEMBL564525 | 0.84 | RAB9A (0.70) | MAPTHPGDRAB9AMAOBESRRA | |
| SCHEMBL2186784 | 0.82 | MAPT (0.79) | MAPTHPGDRAB9AMAOBESRRA | |
| SCHEMBL10726699 | 0.82 | AKR1C3 (0.57) | MAPTTNKSPARP15PARP14PARP10 | |
| SCHEMBL3838552 | 0.82 | SRD5A2 (0.53) | MAPTRAB9ATNKSPARP15PARP14 | |
| SCHEMBL3839157 | 0.82 | ALDH1A1 (0.54) | MAPTMAOBKMT2AMEN1F2 | |
| SCHEMBL3838974 | 0.82 | ALDH1A1 (0.54) | MAPTMAOBKMT2AMEN1F2 | |
| SCHEMBL24489414 | 0.81 | MAPT (0.66) | MAPTHPGDRAB9AMAOBESRRA | |
| SCHEMBL13692140 | 0.81 | MAPT (0.66) | MAPTHPGDRAB9AMAOBESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136200-A | PHENYLBUTANOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-01-23 | — | — | US | disclosed |
| US-4049823-A | Phenylbutanol derivatives and compositions containing them | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-20 | — | — | US | disclosed |