Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136489 | 0.79 | SMN1; SMN2 (0.46) | MAPK1SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL2211208 | 0.79 | SMN1; SMN2 (0.37) | MAPK1SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL533349 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP1A2CYP2C19NPC1RAB9A | |
| SCHEMBL11376339 | 0.78 | PTGS1 (0.51) | SMN1; SMN2CYP1A2KDM4EALDH1A1HTT | |
| SCHEMBL11582679 | 0.76 | SMN1; SMN2 (0.52) | MAPK1SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL10560957 | 0.76 | KDM4A (0.41) | MAPK1SMN1; SMN2CYP1A2CYP2C19KDM4E | |
| SCHEMBL236974 | 0.76 | KDM4A (0.45) | MAPK1SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL20110258 | 0.76 | MAPK1 (0.43) | MAPK1SMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL14007393 | 0.74 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL11073261 | 0.74 | TDP1 (0.63) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4178253-A | 1,2,4-TRIAZOLE COMPOUNDS | CIBA-GEIGY CORPORATION (US) | 1979-12-11 | — | — | US | disclosed |