Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11510661 | 0.88 | SLC6A3 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11509837 | 0.79 | SLC6A3 (0.39) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11507580 | 0.79 | ALDH1A1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11510252 | 0.77 | SLC6A2 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11615267 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL11507289 | 0.77 | KCNJ6 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11507252 | 0.77 | ALDH1A1 (0.39) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11507274 | 0.76 | SLC6A3 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11509784 | 0.76 | PTGS1 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 | |
| SCHEMBL11453328 | 0.76 | MAPT (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160098-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-03 | — | — | US | disclosed |
| US-4122281-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122280-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4096152-A | DIURETICS, SALURETICS, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-4069334-A | DIURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4002641-A | DIURETICS, SALURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | disclosed |