Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11509191 | 0.81 | MAOA (0.52) | MAOAMAOBSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7875349 | 0.81 | MAOA (0.43) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL6825651 | 0.81 | MAOA (0.51) | MAOAMAOBSLC6A4SLC6A2CA1 | |
| SCHEMBL11509987 | 0.81 | MAOA (0.43) | MAOAMAOBSLC6A2SLC6A3MAPT | |
| SCHEMBL5593661 | 0.81 | MAOA (0.43) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL14398424 | 0.77 | MCL1 (0.45) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL148639 | 0.76 | MAOA (0.52) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL5785711 | 0.75 | MAOA (0.52) | MAOAMAOBSLC6A4SLC6A2CA1 | |
| SCHEMBL6822940 | 0.75 | MAOA (0.42) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL9501603 | 0.74 | PTGS2 (0.43) | MAOAMAOBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE29902-E | 6-Aryloxy-2-oxo-1-aza-4-oxo (or thia)-spiro[4,5]decanes as CNS stimulants | CENTRE EUROPEEN DE RECHERCHES MAUVERNAY (FR) | 1979-02-06 | — | — | US | disclosed |
| US-4086352-A | CNS STIMULANTS | CENTRE EUROPEEN DE RECHERCHES MAUVERNAY (FR) | 1978-04-25 | — | — | US | disclosed |
| US-4000292-A | CNS STIMULATORS | CENTRE EUROPEEN DE RECHERCHES MAUVERNAR (FR) | 1976-12-28 | — | — | US | disclosed |