Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11513096 | 0.98 | CYP2D6 (0.43) | CYP2D6NFKB1LMNAMAPTDPP7 | |
| Bromide SCHEMBL11511091 | 0.83 | KDM4E (0.47) | CYP2D6NFKB1LMNAMAPTDPP7 | |
| Bromide SCHEMBL11512431 | 0.83 | DPP7 (0.38) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL11511656 | 0.81 | DPP7 (0.39) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL7943423 | 0.78 | ANPEP (0.49) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL7945922 | 0.78 | ANPEP (0.49) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL15623812 | 0.76 | ALDH1A2 (0.54) | DPP7RRM1GNAI3GNAO1GNAI1 | |
| Bromide SCHEMBL11535126 | 0.75 | DPP7 (0.41) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL23802344 | 0.74 | DPP7 (0.43) | DPP7RRM1SLC15A1GNAI3GNAO1 | |
| SCHEMBL9140084 | 0.73 | USP2 (0.50) | MAPTDPP7RRM1SLC15A1ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139563-A | ENZYME INHIBITORS, ANTIFERTILITY AGENTS, IMMUNOSUPPRESSIVES, ANTITUMOR AGENTS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1979-02-13 | — | — | US | disclosed |