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Sugi Predict / Targets / ALDH1A2

ALDH1A2

Retinal dehydrogenase 2 · O94788 · ALDH1A2 on Sugi Atlas →

7,435 patent compounds predicted against ALDH1A2, 4,759 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL939933 SCHEMBL939933 0.61 14/20
SCHEMBL1753228 SCHEMBL1753228 0.47 10/20
SCHEMBL938243 SCHEMBL938243 0.38 7/20
SCHEMBL1311036 SCHEMBL1311036 0.40 6/20
SCHEMBL973108 SCHEMBL973108 0.70 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1312144) 0.45 4/20
SCHEMBL1689250 SCHEMBL1689250 0.44 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1310831) 0.42 4/20
SCHEMBL2315424 SCHEMBL2315424 0.67 3/20
SCHEMBL1481133 SCHEMBL1481133 0.64 3/20
SCHEMBL2315640 SCHEMBL2315640 0.62 3/20
SCHEMBL221734 SCHEMBL221734 0.56 3/20
SCHEMBL1420335 SCHEMBL1420335 0.55 3/20
SCHEMBL973321 SCHEMBL973321 0.54 3/20
SCHEMBL2257062 SCHEMBL2257062 0.51 3/20
SCHEMBL342144 SCHEMBL342144 0.50 3/20
SCHEMBL970946 SCHEMBL970946 0.50 3/20
SCHEMBL1420384 SCHEMBL1420384 0.49 3/20
SCHEMBL2106057 SCHEMBL2106057 0.48 3/20
SCHEMBL1419869 SCHEMBL1419869 0.47 3/20

Clinical trials — most relevant to ALDH1A2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
A Study of the Beneficial Effects of Eplerenone on Central Serous Chorioretinopathy PHASE2/PHASE3UNKNOWN
Disulfiram for Treatment of Retinal Degeneration PHASE1/PHASE2RECRUITING
Metabolic Mapping to Measure Retinal Metabolism PHASE2COMPLETED
Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa PHASE2UNKNOWN
Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients PHASE2UNKNOWN
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1) PHASE1/PHASE2RECRUITING
ADX-629 Therapy for Sjogren-Larsson Syndrome PHASE1/PHASE2COMPLETED
PDE6A Gene Therapy for Retinitis Pigmentosa PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome PHASE2WITHDRAWN
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa PHASE1COMPLETED
Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye PHASE1COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion nanNOT_YET_RECRUITING
Natural History Study in Patients With PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa nanACTIVE_NOT_RECRUITING
Genetic Association of Diabetic Retinopathy-1 nanUNKNOWN
Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa nanCOMPLETED
Molecular Genetics of Retinal Degenerations nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Biomarkers In Retinitis Pigmentosa (BIRP) nanCOMPLETED
Biomarkers in Retinitis Pigmentosa nanUNKNOWN
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial nanCOMPLETED
Sleep Profile of Patients With Septo-optic Dysplasia nanUNKNOWN
Seven Year Update of Macular Degeneration Patients nanCOMPLETED
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
Natural History Study of Inherited Retinal Diseases nanRECRUITING
Study on the Effects of Mutations Under Inherited Retinal Disease in Korean nanCOMPLETED
Rate of Progression in USH2A-related Retinal Degeneration nanACTIVE_NOT_RECRUITING
Autosomal Dominant Retinitis Pigmentosa: Prevalence of Known Genes Identification of New Loci / Genes nanCOMPLETED
Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65 nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALDH1A2 binder may also engage these)

ProteinNameSimilarity
Q63639 — 1.000 Q63639 →
Q62148 — 1.000 Q62148 →
O93344 — 1.000 O93344 →
Q9I8W8 — 0.999 Q9I8W8 →
P81178 — 0.998 P81178 →
P51977 — 0.997 P51977 →
ALDH1A3 Retinaldehyde dehydrogenase 3 0.997 landscape →
ALDH1A1 Aldehyde dehydrogenase 1A1 0.996 landscape →
Q9JHW9 — 0.996 Q9JHW9 →
P48644 — 0.996 P48644 →
ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 0.996 landscape →
P28237 — 0.996 P28237 →
Q8HYE4 — 0.996 Q8HYE4 →
Q88AE9 — 0.995 Q88AE9 →
Q4ZM62 — 0.995 Q4ZM62 →
Q2XQV4 — 0.994 Q2XQV4 →
P54115 — 0.994 P54115 →
Q9CZS1 — 0.994 Q9CZS1 →
Q56R04 — 0.994 Q56R04 →
Q9SU63 — 0.994 Q9SU63 →
Q8K4D8 — 0.994 Q8K4D8 →
Q25417 — 0.994 Q25417 →
P15437 — 0.993 P15437 →
B7MCD1 — 0.993 B7MCD1 →
P13601 — 0.993 P13601 →
Q48CM6 — 0.993 Q48CM6 →
Q29490 — 0.993 Q29490 →
Q27640 — 0.993 Q27640 →
Q3K5H4 — 0.993 Q3K5H4 →
P27463 — 0.993 P27463 →