SCHEMBL11512909

SCHEMBL11512909

C=CCCCC(=O)CCCCl

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.45
ABCC4 O15439 1/20 0.45
ALDH1A1 P00352 5/20 0.39
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.34
TSHR P16473 3/20 0.33
FAAH O00519 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
USP2 O75604 1/20 0.32
CYP3A4 P08684 1/20 0.32
RECQL P46063 1/20 0.32
LPAR2 Q9HBW0 1/20 0.31
LPAR3 Q9UBY5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10373212 0.91 MAPT (0.40) MAPTABCC4ALDH1A1LMNAL3MBTL1
SCHEMBL4441350 0.88 MAPT (0.54) MAPTABCC4ALDH1A1LMNAL3MBTL1
SCHEMBL4446966 0.80 MAPT (0.65) MAPTABCC4ALDH1A1LMNATSHR
SCHEMBL1685807 0.80 TSHR (0.40) MAPTALDH1A1LMNATSHRFAAH
SCHEMBL1737241 0.79
SCHEMBL5612431 0.78 MAPT (0.70) MAPTABCC4ALDH1A1LMNATSHR
SCHEMBL13935003 0.78
SCHEMBL5363934 0.78 MAPT (0.70) MAPTABCC4ALDH1A1LMNATSHR
SCHEMBL3960154 0.78 MAPT (0.70) MAPTABCC4ALDH1A1LMNATSHR
SCHEMBL3170373 0.78 MAPT (0.70) MAPTABCC4ALDH1A1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4175203-A TREATMENT OF RENAL FAILURE AND TRANSPLANT REJECTION VASODILATORS MERCK & CO., INC. (US) 1979-11-20 US disclosed
US-4155908-A PSORIASIS, ANTICOAGULANTS MERCK & CO., INC. (US) 1979-05-22 US disclosed
US-4150235-A ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR MERCK & CO., INC. (US) 1979-04-17 US disclosed
US-4140861-A RENAL DISFUNCTION, ANTIBODY INHIBITORS MERCK & CO., INC. (US) 1979-02-20 US disclosed
US-4128564-A 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins MERCK & CO., INC. (US) 1978-12-05 US disclosed
US-4112236-A Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins MERCK & CO., INC. (US) 1978-09-05 US disclosed
US-4097504-A 11,12-Secoprostaglandins MERCK & CO., INC. (US) 1978-06-27 US disclosed
US-4092356-A 11,12-Secoprostaglandins MERCK & CO., INC. (US) 1978-05-30 US disclosed
US-4091107-A RENAL VASODILATORS, ANTICLOTTING AGENTS, GROWTH HORMONE RELEASE, REGULATORS OF IMMUNE RESPONSE MERCK & CO., INC. (US) 1978-05-23 US disclosed
US-4085125-A 9-Thia-, 9-oxothia-, and 9-dioxothia-11,12-seco-prostaglandins and processes MERCK & CO., INC. (US) 1978-04-18 US disclosed
US-4066692-A 11,12-SECOPROSTAGLANDINS MERCK & CO., INC. (US) 1978-01-03 US disclosed
US-4066675-A PSORIASIS, THROMBOSIS MERCK & CO., INC. (US) 1978-01-03 US disclosed
US-4055597-A RENAL VASODILATORS MERCK & CO., INC. (US) 1977-10-25 US disclosed
US-4033996-A RENAL VASODILATORS, ANTITHROMBOSIS, GROWTH HORMONE RELEASING MERCK & CO., INC. (US) 1977-07-05 US disclosed
US-4018802-A SKIN DISEASES, GROWTH HORMONE STIMULANTS, THROMBUS PREVENTION, IMMUNOLOGY MERCK & CO., INC. (US) 1977-04-19 US disclosed
US-3989749-A RENAL VASODILATORS, ANTITHROMBUS MERCK & CO., INC. (US) 1976-11-02 US disclosed
US-3987091-A RENAL VASODILATORS MERCK & CO., INC. (US) 1976-10-19 US disclosed