⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2136226 | 0.85 | — | — | |
| SCHEMBL11512909 | 0.79 | MAPT (0.45) | — | |
| SCHEMBL10373212 | 0.79 | MAPT (0.40) | — | |
| SCHEMBL3627376 | 0.79 | ALDH1A1 (0.35) | — | |
| SCHEMBL10374940 | 0.76 | — | — | |
| SCHEMBL5363940 | 0.76 | — | — | |
| SCHEMBL11870573 | 0.76 | SLC22A6 (0.52) | — | |
| SCHEMBL9101926 | 0.76 | — | — | |
| SCHEMBL7698896 | 0.76 | MAPT (0.58) | — | |
| SCHEMBL28426128 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111393275-A | Method for synthesizing intermediate farnesyl acetone and method for synthesizing phytol, isophytol and geranylgeraniol by using intermediate farnesyl acetone | 上海现代哈森（商丘）药业有限公司 | 2020-07-10 | — | — | CN | claimed |
| EP-1420021-A1 | DNA Methyltransferase inhibitors | The Penn State Research Foundation (US) | 2004-05-19 | — | — | EP | claimed |
| JP-2003501431-A | — | — | 2003-01-14 | — | — | JP | claimed |
| EP-1181291-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075142-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2000-12-14 | — | — | WO | claimed |
| CN-109689645-B | Cyanoindoline derivatives as NIK inhibitors | 杨森制药有限公司 | 2022-06-03 | — | — | CN | disclosed |
| US-11186589-B2 | Cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-30 | — | — | US | disclosed |
| US-20210032267-A1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | US | disclosed |
| EP-3478673-B1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-16 | — | — | EP | disclosed |
| CN-111393275-A | Method for synthesizing intermediate farnesyl acetone and method for synthesizing phytol, isophytol and geranylgeraniol by using intermediate farnesyl acetone | 上海现代哈森（商丘）药业有限公司 | 2020-07-10 | — | — | CN | disclosed |
| EP-3478673-A1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2019-05-08 | — | — | EP | disclosed |
| US-20190119299-A1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-04-25 | — | — | US | disclosed |
| US-4181665-A | INTERMEDIATES FOR AMINO DERIVATIVES POSSESSING HYPOTENSIVE AND CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1980-01-01 | — | — | US | disclosed |
| US-4179510-A | ISOCHROMANS AND 2-BENZOXEPINS | THE UPJOHN COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4166062-A | HYPOTENSIVE AGENTS, CNS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-08-28 | — | — | US | disclosed |
| US-4163053-A | Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides | SCHERING CORPORATION (US) | 1979-07-31 | — | — | US | disclosed |
| EP-0002867-A1 | 5-(2-Anilinoalkylamino-1-hydroxyalkyl)salicylamides, their preparation and anti-hypertensive compositions containing them | Technobiotic Ltd. (CH) | 1979-07-11 | — | — | EP | disclosed |
| US-4158012-A | Steroid synthesis process using mixed anhydride | SYNTEX (U.S.A.) INC. (US) | 1979-06-12 | — | — | US | disclosed |
| US-4153612-A | 2-Benzoxepins | THE UPJOHN COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4018930-A | ANALGESICS, SEDATIVES, TRANQUILIZERS | ENDO LABORATORIES, INC. (US) | 1977-04-19 | — | — | US | disclosed |