Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 11/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30785151 | 0.95 | TET2 (0.37) | TET2EGFRKDM4AKDM4CKDM5A | |
| SCHEMBL22345 | 0.95 | TET2 (0.37) | TET2EGFRKDM4AKDM4CKDM5A | |
| Ammonia Solution, Strong SCHEMBL9070321 | 0.93 | TET2 (0.35) | TET2EGFRKDM4AKDM4CKDM5A | |
| Hydrochloric Acid SCHEMBL1155810 | 0.93 | KDM4A (0.37) | TET2EGFRKDM4AKDM4CKDM5A | |
| Bromomethane SCHEMBL7095815 | 0.91 | TET2 (0.34) | TET2EGFRKDM4AKDM4CKDM5A | |
| Chloromethane SCHEMBL124968 | 0.91 | TET2 (0.39) | TET2EGFRKDM4AKDM4CKDM5A | |
| Hydrochloric Acid SCHEMBL28345645 | 0.91 | KDM4A (0.36) | TET2EGFRKDM4AKDM4CKDM5A | |
| SCHEMBL4242756 | 0.87 | KDM4A (0.38) | PAOXKDM4AKDM4CKDM5AKDM7A | |
| Sulfuric Acid SCHEMBL1155538 | 0.87 | GSR (0.36) | TET2EGFRPAOXKDM4AKDM4C | |
| SCHEMBL8736374 | 0.87 | MAPT (0.39) | TET2EGFRPAOXKDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4148949-A | Method of increasing polymerization reaction rates in the production of a fiber-thermoplastic matrix by in situ bulk polymerization | WEYERHAEUSER COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4051214-A | METHOD OF CONTROLLING MONOMER LOSS DURING THE PRODUCTION OF A FIBER-THERMOPLASTIC MATRIX BY IN SITU BULK POLYMERIZATION | WEYERHAEUSER COMPANY (US) | 1977-09-27 | — | — | US | disclosed |