SCHEMBL11513595

SCHEMBL11513595

CCOC(=O)C(C)Oc1ccc(Sc2ccc(C(F)(F)F)cc2C#N)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.44
KMT2A Q03164 1/20 0.40
XDH P47989 1/20 0.40
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
POLB P06746 2/20 0.37
KDM4E B2RXH2 2/20 0.37
HTT P42858 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
MAPT P10636 2/20 0.37
CYP3A4 P08684 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
ACACB O00763 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
PTGS2 P35354 1/20 0.36
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11514214 0.90 XDH (0.47) IDH1KMT2AXDHLMNAL3MBTL1
SCHEMBL11515623 0.88 PTGDR2 (0.46) XDHLMNAPOLBKDM4EHTT
SCHEMBL11512107 0.87 CYP2C19 (0.41) KMT2AXDHLMNAPOLBKDM4E
SCHEMBL11511760 0.87 XDH (0.40) KMT2AXDHLMNAPOLBKDM4E
SCHEMBL11516084 0.85 IDH1 (0.46) IDH1KMT2ALMNAL3MBTL1POLB
SCHEMBL11514550 0.85 IDH1 (0.46) IDH1KMT2ALMNAL3MBTL1POLB
SCHEMBL11262145 0.85 IDH1 (0.46) IDH1KMT2ALMNAL3MBTL1POLB
SCHEMBL11514770 0.85 IDH1 (0.46) IDH1KMT2ALMNAL3MBTL1POLB
SCHEMBL11512279 0.84 IDH1 (0.45) IDH1KMT2ALMNAL3MBTL1POLB
SCHEMBL11512703 0.83 IDH1 (0.43) IDH1KMT2AXDHL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4178169-A Diphenyl sulfide, sulfoxide and sulfone plant growth regulators ROHM AND HAAS COMPANY (US) 1979-12-11 US disclosed