SCHEMBL11513706

SCHEMBL11513706

CC(C)(C)C(=O)C(Br)Oc1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
AKR1C4 P17516 1/20 0.33
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
AKR1C1 Q04828 1/20 0.33
CYP3A4 P08684 2/20 0.33
MEN1 O00255 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
CHRM1 P11229 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CXCR5 P32302 1/20 0.32
ACLY P53396 1/20 0.32
GRN P28799 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11513046 0.83 POLB (0.39) CYP3A4MEN1SLC6A4ADRA1AKMT2A
SCHEMBL11004556 0.81 CNR1 (0.42) KMT2ACXCR5ACLYPPARA
SCHEMBL11511837 0.80 SMN1; SMN2 (0.51) CYP3A4MEN1KMT2ASMN1; SMN2PPARA
SCHEMBL11512255 0.79 CYP3A4 (0.30) CYP3A4MEN1ADORA3CHRM1SLC6A2
SCHEMBL11845929 0.77 LMNA (0.39) MEN1KMT2ASMN1; SMN2
SCHEMBL11512850 0.76 GAA (0.41) CYP3A4MEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL8496952 0.75 CYP3A4 (0.51) CYP3A4MEN1ADORA3CHRM1SLC6A2
SCHEMBL11437443 0.74 MAPT (0.35) CA2MEN1KMT2APDK1PDK2
SCHEMBL11513712 0.74 OGG1 (0.49) ADORA3SLC6A2SLC6A4SLC6A3KMT2A
SCHEMBL11513946 0.72 TSHR (0.56) MEN1KMT2ASMN1; SMN2KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4147791-A 1-Substituted-1,2,4-triazole fungicidal compositions and methods for combatting fungi that infect or attack plants BAYER AKTIENGESELLSCHAFT (DE) 1979-04-03 US disclosed
US-4048318-A 1-Substituted-1,2,4-triazole fungicides BAYER AKTIENGESELLSCHAFT (DT) 1977-09-13 US disclosed