Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11514911 | 1.00 | PDE4D (0.48) | PDE4DPRKCACA12CA2CA7 | |
| SCHEMBL14224913 | 0.83 | PDE4D (0.61) | PDE4DPRKCAEPHX2 | |
| SCHEMBL14224961 | 0.83 | PDE4D (0.61) | PDE4DPRKCAEPHX2 | |
| SCHEMBL11512549 | 0.79 | PRKCA (0.47) | PRKCACA12CA2CA7CA9 | |
| SCHEMBL11513293 | 0.78 | PDE4D (0.46) | PDE4DPRKCAEPHX2 | |
| SCHEMBL11513290 | 0.78 | PDE4D (0.46) | PDE4DPRKCAEPHX2 | |
| SCHEMBL13764839 | 0.75 | PDE4D (0.51) | PDE4DPRKCAPPARG | |
| SCHEMBL11513721 | 0.75 | PRKCA (0.38) | PDE4DPRKCACA12CA2CA7 | |
| SCHEMBL11515100 | 0.75 | PRKCA (0.38) | PDE4DPRKCACA12CA2CA7 | |
| SCHEMBL11513718 | 0.75 | PRKCA (0.38) | PDE4DPRKCACA12CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4155908-A | PSORIASIS, ANTICOAGULANTS | MERCK & CO., INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4128564-A | 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins | MERCK & CO., INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4085125-A | 9-Thia-, 9-oxothia-, and 9-dioxothia-11,12-seco-prostaglandins and processes | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |
| US-4066675-A | PSORIASIS, THROMBOSIS | MERCK & CO., INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4018802-A | SKIN DISEASES, GROWTH HORMONE STIMULANTS, THROMBUS PREVENTION, IMMUNOLOGY | MERCK & CO., INC. (US) | 1977-04-19 | — | — | US | disclosed |