Barbituric Acid

Barbituric Acid

SCHEMBL11515465

O=C1CC(=O)NC(=O)N1.Oc1cc(O)c2ccccc2n1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GUSB P08236 7/20 0.39
KDM4E B2RXH2 2/20 0.38
HPGD P15428 1/20 0.38
ELANE P08246 2/20 0.37
MYC P01106 1/20 0.37
MAX P61244 1/20 0.37
PLAUR Q03405 1/20 0.36
PARP1 P09874 3/20 0.35
TNKS2 Q9H2K2 2/20 0.35
TNKS O95271 1/20 0.35
ALDH1A1 P00352 2/20 0.35
PARP2 Q9UGN5 1/20 0.35
CYP1A1 P04798 2/20 0.34
CYP1B1 Q16678 2/20 0.34
CYP1A2 P05177 1/20 0.34
QTRT1 Q9BXR0 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL64767 0.80 MYC (0.52) GUSBKDM4EHPGDMYCMAX
SCHEMBL29376440 0.80 MYC (0.52) GUSBKDM4EHPGDMYCMAX
SCHEMBL11811414 0.79 MYC (0.50) GUSBKDM4EHPGDMYCMAX
SCHEMBL11811408 0.79 MYC (0.50) GUSBKDM4EHPGDMYCMAX
SCHEMBL10775534 0.68 KMT2A (0.42) MYCMAXPOLB
Biphenyl SCHEMBL1855900 0.67 TDP2 (0.52) KDM4EHPGDALDH1A1CYP1A2
Barbituric Acid SCHEMBL1470199 0.66 HSD17B10 (0.50) KDM4EHPGDALDH1A1CYP1A2
Barbituric Acid SCHEMBL5051030 0.66 TDP2 (0.50) ALDH1A1
SCHEMBL9326676 0.66 MYC (0.52) KDM4EHPGDMYCMAXALDH1A1
Barbituric Acid SCHEMBL11359266 0.64 TSHR (0.48) HPGDALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4159264-A Automatic control of azo coupling processes in the manufacture of azo pigments CIBA-GEIGY CORPORATION (US) 1979-06-26 US claimed