Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18274692 | 0.98 | ALDH1A1 (0.35) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL3506816 | 0.84 | LMNA (0.34) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL3506823 | 0.84 | LMNA (0.34) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL3507188 | 0.84 | LMNA (0.34) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL23656867 | 0.79 | SLC7A5 (0.44) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL14989440 | 0.79 | MAPT (0.41) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL14887353 | 0.79 | MAPT (0.41) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL14887474 | 0.79 | MAPT (0.41) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL14989441 | 0.79 | MAPT (0.41) | LMNACYP2C9CHRM2CHRM4CHRM1 | |
| SCHEMBL15574890 | 0.79 | MAPT (0.41) | LMNACYP2C9CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |