Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519977 | 0.90 | AKR1B1 (0.58) | AKR1B1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11517611 | 0.89 | AKR1B1 (0.53) | AKR1B1ALDH1A1MAPTMEN1PKM | |
| SCHEMBL11519465 | 0.89 | AKR1B1 (0.69) | AKR1B1ALDH1A1MAPTMEN1PKM | |
| SCHEMBL11520526 | 0.86 | AKR1B1 (0.54) | AKR1B1ALDH1A1MAPTPTGS1PTGS2 | |
| SCHEMBL11519573 | 0.84 | AKR1B1 (0.76) | AKR1B1ALDH1A1MAPTMEN1PKM | |
| SCHEMBL11517083 | 0.80 | AKR1B1 (0.72) | AKR1B1ALDH1A1MAPTMEN1PKM | |
| SCHEMBL11843846 | 0.79 | AKR1B1 (0.51) | AKR1B1PTGS1PTGS2CES1L3MBTL1 | |
| SCHEMBL11517540 | 0.78 | AKR1B1 (0.67) | AKR1B1ALDH1A1MAPTMEN1PKM | |
| SCHEMBL11520301 | 0.75 | AKR1B1 (0.68) | AKR1B1MAPTMEN1PKMKMT2A | |
| SCHEMBL11518749 | 0.74 | AKR1B1 (0.44) | AKR1B1ALDH1A1MAPTMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172949-A | 2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes | SYNTEX (U.S.A.) INC. (US) | 1979-10-30 | — | — | US | disclosed |