⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1813329 | 0.72 | NPC1 (0.37) | — | |
| SCHEMBL17551961 | 0.72 | — | — | |
| SCHEMBL29778088 | 0.67 | — | — | |
| SCHEMBL14865436 | 0.67 | TRPV4 (0.31) | — | |
| SCHEMBL25404298 | 0.67 | — | — | |
| SCHEMBL163787 | 0.67 | — | — | |
| SCHEMBL724513 | 0.67 | — | — | |
| SCHEMBL5030163 | 0.67 | — | — | |
| SCHEMBL1867413 | 0.67 | — | — | |
| SCHEMBL12301380 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025038395-A1 | BENZOPYRIDINONES AND BENZOPYRIMIDINONES AS PI3K INHIBITORS | ONKURE, INC. (US) | 2025-02-20 | — | — | WO | disclosed |
| US-20240182446-A1 | TYK2 INHIBITOR COMPOUND CONTAINING BICYCLIC RING | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-06 | — | — | US | disclosed |
| EP-4289833-A1 | TYK2 INHIBITOR COMPOUND CONTAINING BICYCLIC RING | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-12-13 | — | — | EP | disclosed |
| EP-4289833-A1 | TYK2 INHIBITOR COMPOUND CONTAINING BICYCLIC RING | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-12-13 | — | — | EP | disclosed |
| CN-116783178-A | Bicyclic TYK2 inhibitor compounds | 正大天晴药业集团股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022166917-A1 | TYK2 INHIBITOR COMPOUND CONTAINING BICYCLIC RING | 正大天晴药业集团股份有限公司 | 2022-08-11 | — | — | WO | disclosed |
| CN-104540815-B | Arylethynyl Derivatives | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |
| EP-2882742-B1 | ARYLETHYNYL PYRIMIDINES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| EP-2702050-B1 | PYRAZOLIDIN-3-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| CN-104395297-B | Sulfonamide derivatives and pharmaceutical use thereof | AJINOMOTO CO.,INC. (JP) | 2016-05-04 | — | — | CN | disclosed |
| US-7851625-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7851625-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7642352-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| US-7642352-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| WO-2009143945-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH, (DE) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009129905-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-10-29 | — | — | WO | disclosed |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-6872824-B2 | Pyrimidine spirobifluorene oligomer for organic light-emitting device | ECHEM HIGHTECH CO., LTD. (TW) | 2005-03-29 | — | — | US | disclosed |
| US-20040147742-A1 | Pyrimidine spirobifluorene oligomer for organic light-emitting device | NATIONAL TAIWAN UNIVERSITY (TW) | 2004-07-29 | — | — | US | disclosed |