SCHEMBL11519362

SCHEMBL11519362

COc1ccc2[nH]c(C)c(CCN3CCC(CCC4CCCCC4)CC3)c2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.54
GAA P10253 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
KDM4E B2RXH2 4/20 0.53
MAPT P10636 2/20 0.53
TSHR P16473 1/20 0.53
HTR1D P28221 2/20 0.53
HTR6 P50406 2/20 0.53
HSD17B10 Q99714 4/20 0.53
HPGD P15428 1/20 0.53
HTR1A P08908 1/20 0.51
SLC6A2 P23975 1/20 0.51
HTR1E P28566 1/20 0.51
HTR7 P34969 1/20 0.51
HTR5A P47898 1/20 0.51
MTNR1A P48039 2/20 0.50
MTNR1B P49286 2/20 0.50
HTR2A P28223 2/20 0.47
ALOX15 P16050 1/20 0.47
AKR1C2 P52895 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11524195 0.99 ALDH1A1 (0.55) ALDH1A1GAASMN1; SMN2KDM4EMAPT
Hydrochloric Acid SCHEMBL11522973 0.88 ALDH1A1 (0.56) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11520500 0.86 ALDH1A1 (0.55) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11517681 0.82 ALDH1A1 (0.53) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11520036 0.82 HTR1D (0.62) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11524016 0.81 ALDH1A1 (0.55) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11519836 0.81 ALDH1A1 (0.55) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL9090770 0.80 ALDH1A1 (0.61) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11520569 0.80 HSD17B10 (0.71) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11520933 0.79 ALDH1A1 (0.61) ALDH1A1GAASMN1; SMN2KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4160862-A ANTIINFLAMMATORY STERLING DRUG INC. (US) 1979-07-10 US disclosed
US-4021431-A ANTIINFLAMMATORY AGENTS STERLING DRUG INC. (US) 1977-05-03 US disclosed