Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11777945 | 1.00 | NAAA (0.61) | NAAAEPHX1HCAR2TSHRRAD52 | |
| Bicarbonate SCHEMBL11523280 | 1.00 | NAAA (0.61) | NAAAEPHX1HCAR2TSHRRAD52 | |
| Bicarbonate SCHEMBL27833264 | 1.00 | NAAA (0.61) | NAAAEPHX1HCAR2TSHRRAD52 | |
| Bicarbonate SCHEMBL11521639 | 1.00 | NAAA (0.61) | NAAAEPHX1HCAR2TSHRRAD52 | |
| Bicarbonate SCHEMBL27341079 | 0.98 | NAAA (0.58) | NAAAEPHX1HCAR2TSHRRAD52 | |
| Bicarbonate SCHEMBL2357034 | 0.98 | NAAA (0.58) | NAAAEPHX1HCAR2TSHRRAD52 | |
| SCHEMBL1835519 | 0.95 | NAAA (0.67) | NAAAEPHX1HCAR2TSHRRAD52 | |
| SCHEMBL4934658 | 0.95 | NAAA (0.67) | NAAAEPHX1HCAR2TSHRRAD52 | |
| SCHEMBL1837444 | 0.95 | NAAA (0.67) | NAAAEPHX1HCAR2TSHRRAD52 | |
| SCHEMBL1839498 | 0.95 | NAAA (0.67) | NAAAEPHX1HCAR2TSHRRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159943-A | Froth flotation of ores using hydrocarbyl bicarbonates | PETROVICH VOJISLAV | 1979-07-03 | — | — | US | disclosed |