Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27341079 | 1.00 | NAAA (0.58) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| Bicarbonate SCHEMBL11520679 | 0.98 | NAAA (0.61) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| Bicarbonate SCHEMBL27833264 | 0.98 | NAAA (0.61) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| Bicarbonate SCHEMBL11521639 | 0.98 | NAAA (0.61) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| Bicarbonate SCHEMBL11777945 | 0.98 | NAAA (0.61) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| Bicarbonate SCHEMBL11523280 | 0.98 | NAAA (0.61) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| SCHEMBL37366 | 0.95 | NAAA (0.62) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| SCHEMBL1835519 | 0.92 | NAAA (0.67) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| SCHEMBL1841329 | 0.92 | NAAA (0.67) | NAAAHCAR2EPHX1ALDH1A1TSHR | |
| SCHEMBL1839498 | 0.92 | NAAA (0.67) | NAAAHCAR2EPHX1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023058681-A1 | METHOD FOR PRODUCING HIGH-PURITY DIARYL CARBONATE | 旭化成株式会社 | 2023-04-13 | — | — | WO | disclosed |
| US-8620127-B2 | Optical waveguide and method for manufacturing the same | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2013-12-31 | — | — | US | disclosed |
| US-20110188827-A1 | OPTICAL WAVEGUIDE AND METHOD FOR MANUFACTURING THE SAME | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2011-08-04 | — | — | US | disclosed |
| EP-2237089-A1 | OPTICAL WAVEGUIDE AND METHOD FOR MANUFACTURING THE SAME | Hitachi Chemical Company, Ltd. (JP) | 2010-10-06 | — | — | EP | disclosed |
| EP-1923352-B1 | Negative active material for rechargeable lithium battery, method of preparing the same, and rechargeable lithium battery including the same | SAMSUNG SDI CO LTD (KR) | 2010-06-23 | — | — | EP | disclosed |
| US-20080118841-A1 | NEGATIVE ACTIVE MATERIAL FOR RECHARGEABLE LITHIUM BATTERY, METHOD OF PREPARING THE SAME, AND RECHARGEABLE LITHIUM BATTERY INCLUDING THE SAME | SAMSUNG SDI CO., LTD. (KR) | 2008-05-22 | — | — | US | disclosed |
| EP-1923352-A2 | Negative active material for rechargeable lithium battery, method of preparing the same, and rechargeable lithium battery including the same | Samsung SDI Co., Ltd. (KR) | 2008-05-21 | — | — | EP | disclosed |