Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353782 | 0.83 | APEX1 (0.62) | APEX1BLMLMNATP53SMN1; SMN2 | |
| SCHEMBL10582437 | 0.83 | APEX1 (0.57) | APEX1BLMLMNATP53SMN1; SMN2 | |
| SCHEMBL9628959 | 0.81 | APEX1 (0.69) | APEX1BLMLMNATP53SMN1; SMN2 | |
| SCHEMBL9208638 | 0.81 | APEX1 (0.59) | APEX1BLMLMNATP53SMN1; SMN2 | |
| SCHEMBL9208632 | 0.81 | APEX1 (0.59) | APEX1BLMLMNATP53SMN1; SMN2 | |
| SCHEMBL11107180 | 0.79 | APEX1 (0.65) | APEX1BLMLMNATP53TSHR | |
| SCHEMBL9851227 | 0.78 | APEX1 (0.48) | APEX1BLMLMNATP53MEN1 | |
| SCHEMBL14426907 | 0.78 | APEX1 (0.68) | APEX1BLMTP53SMN1; SMN2POLB | |
| SCHEMBL11107187 | 0.77 | APEX1 (0.54) | APEX1BLMLMNATP53 | |
| SCHEMBL21389170 | 0.77 | APEX1 (0.62) | APEX1BLMLMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4173569-A | Preparation of pyrrolidine and pyrrolidin-2-one derivatives | I.S.F. SPA (IT) | 1979-11-06 | — | — | US | disclosed |
| US-4124594-A | REACTING AMINO-HYDROXYBUTYRIC ACID WITH A SILYLATING AGENT FOLLOWED BY REACTION WITH A HALOGENATED ESTER, CYCLIZATION | I.S.F. SPA (IT) | 1978-11-07 | — | — | US | disclosed |