Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norfloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.98 |
| ▸ | HPGD | P15428 | 6/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.98 |
| ▸ | LMNA | P02545 | 5/20 | 0.98 |
| ▸ | HTT | P42858 | 3/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | BRD4 | O60885 | 1/20 | 0.98 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.98 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | TOP2A | P11388 | 1/20 | 0.66 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norfloxacin SCHEMBL9788079 | 1.00 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28112643 | 1.00 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL2221304 | 0.99 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL27395494 | 0.99 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3473 | 0.99 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28495826 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10911469 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3147077 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10886039 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL27878728 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4146719-A | ANTIBACTERIAL AGENTS | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1979-03-27 | — | — | US | claimed |