Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norfloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | BRD4 | O60885 | 1/20 | 1.00 |
| ▸ | CYP2J2 | P51589 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TOP2A | P11388 | 1/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norfloxacin SCHEMBL2221304 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL27395494 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL9788079 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10886039 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28112643 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3147077 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28495826 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10911469 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL11524201 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL27878728 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 52917 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076078-A | Filtering device for norfloxacin production | — | 2026-05-26 | — | — | CN | claimed |
| CN-116448860-B | Norfloxacin sensor, preparation method and detection method thereof | CHENGDU NORMAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122081335-A | Nucleic acid aptamer OUC-NOR7-2T of norfloxacin and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076471-A | Metal basic salt mineralized membrane, preparation method thereof and application of metal basic salt mineralized membrane serving as heterogeneous catalyst in treatment of organic wastewater | — | 2026-05-26 | — | — | CN | claimed |
| CN-117185291-B | Preparation method and application of sodium lignin sulfonate-based porous carbon | Institute of Chemical Industry of Forest Products, CAF (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| CN-122057521-A | LaFeO3@FeIn2S4 photocatalytic material with core-shell structure, preparation method thereof and application thereof in photo-induced persulfate oxidative degradation of tetracycline antibiotics | 中国科学院青海盐湖研究所 | 2026-05-19 | — | — | CN | claimed |
| CN-122036889-A | Cyclized antibacterial peptide CycP-1 of targeted multi-drug resistant klebsiella pneumoniae, composition and application thereof | 湖北江夏实验室 | 2026-05-15 | — | — | CN | claimed |
| CN-117899897-B | Cathode catalyst and application thereof in norfloxacin wastewater treatment | 山东农业大学 | 2026-05-15 | — | — | CN | claimed |
| US-4404197-A | Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine | RESEARCH CORPORATION A NEW YORK NOT-FOR-PROFIT CORP | 1983-09-13 | — | — | US | claimed |
| EP-0084011-A1 | Quinoline carboxylic acid complexes with guanidinium carbonate and guanidine | MERCK & CO. INC. (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0083032-A2 | Rectally administrable suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1983-07-06 | — | — | EP | claimed |
| EP-0069385-A2 | Use of eucalyptol for enhancing skin permeation of bioaffecting agents | MERCK & CO. INC. (US) | 1983-01-12 | — | — | EP | claimed |
| EP-0067666-A1 | Salts of antimicrobial naphthyridine and quinoline compounds and their production | WARNER-LAMBERT COMPANY (US) | 1982-12-22 | — | — | EP | claimed |
| EP-0049593-A1 | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy | Fox, Charles l., Jr. (US) | 1982-04-14 | — | — | EP | claimed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | claimed |
| US-4146719-A | ANTIBACTERIAL AGENTS | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1979-03-27 | — | — | US | claimed |