SCHEMBL11524993

SCHEMBL11524993

CCOC(=O)C1=C(C)NC(N)=C(C(=O)OCC)C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 7/20 0.67
CACNA1D Q01668 7/20 0.67
CACNA1F O60840 5/20 0.67
CACNA1S Q13698 5/20 0.67
ADORA3 P0DMS8 4/20 0.67
CYP1A2 P05177 3/20 0.67
ABCC4 O15439 2/20 0.67
ABCB11 O95342 2/20 0.67
LMNA P02545 2/20 0.67
ADORA2A P29274 2/20 0.67
ADORA1 P30542 2/20 0.67
OPRM1 P35372 2/20 0.67
SCN1A P35498 2/20 0.67
HTR2B P41595 2/20 0.67
KCNH2 Q12809 2/20 0.67
SCN5A Q14524 2/20 0.67
SCN2A Q99250 2/20 0.67
SCN3A Q9NY46 2/20 0.67
CACNA1B Q00975 2/20 0.67
MAPT P10636 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11689121 0.96 ADORA3 (0.75) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL11669900 0.94 CACNA1C (0.60) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL29810716 0.93 CACNA1C (0.77) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL1617472 0.93 CACNA1C (0.77) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL11689797 0.93 CACNA1D (0.62) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL10902631 0.91 CACNA1C (0.59) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL11527403 0.90 CACNA1C (0.60) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL5085498 0.88 ADORA3 (0.86) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL7412221 0.88 CACNA1B (0.74) CACNA1CCACNA1DCACNA1FCACNA1SADORA3
SCHEMBL8091424 0.88 CACNA1C (0.70) CACNA1CCACNA1DCACNA1FCACNA1SADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4146627-A AMINOALKYLIDEAMINO-1,4-DIHYDROPYRIDINES AND THEIR USE AS MEDICAMENTS BAYER AKTIENGESELLSCHAFT (DE) 1979-03-27 US disclosed
US-4022898-A ANTIHYPERTENSIVE AGENTS, VASODILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-05-10 US disclosed
US-4001235-A HYPOTENSIVES, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-4001258-A HYPOTENSIVES, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-3971790-A VASODILATION, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3971791-A VASODILATION, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3946026-A HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-03-23 US disclosed
US-3939171-A HYPOTENSIVE, VASODILATION BAYER AKTIENGESELLSCHAFT (DT) 1976-02-17 US disclosed
US-3935223-A 2-Amino-1,4-dihydropyridine derivatives BAYER AKTIENGESELLSCHAFT (DT) 1976-01-27 US disclosed