Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 3/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18486808 | 0.87 | DOT1L (0.56) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL18483493 | 0.87 | DOT1L (0.56) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL18483516 | 0.85 | DOT1L (0.54) | ADKDOT1LPAX8HIF1APRMT5 | |
| SCHEMBL1738396 | 0.85 | ADK (0.51) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL6727268 | 0.85 | ADK (0.51) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL6737734 | 0.85 | ADK (0.51) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL1738360 | 0.85 | ADK (0.51) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL11529405 | 0.85 | HIF1A (0.51) | ADKDOT1LLMNATP53PAX8 | |
| SCHEMBL19101800 | 0.83 | ADK (0.52) | ADKDOT1LPAX8HIF1AADORA2A | |
| SCHEMBL18483513 | 0.83 | ADK (0.52) | ADKDOT1LPAX8HIF1AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140851-A | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1979-02-20 | — | — | US | claimed |
| US-4140851-A | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1979-02-20 | — | — | US | disclosed |