Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11520972 | 0.85 | RAB9A (0.45) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11523355 | 0.82 | TYK2 (0.37) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11525157 | 0.81 | MAPT (0.48) | MAPTGHSRRAB9ANPC1MEN1 | |
| SCHEMBL11526021 | 0.80 | PLK1 (0.41) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11523714 | 0.79 | RAB9A (0.43) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11525837 | 0.78 | CNR1 (0.42) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11523661 | 0.77 | MAPT (0.43) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11521741 | 0.77 | GAA (0.42) | TYK2JAK2JAK1MAPTGHSR | |
| SCHEMBL11523601 | 0.77 | PPIA (0.43) | TYK2JAK2JAK1MAPK14MAPT | |
| SCHEMBL11526310 | 0.77 | DHODH (0.43) | MAPTGHSRRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |