Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11525157 | 0.88 | MAPT (0.48) | RAB9ANPC1MAPTGHSRITGB1 | |
| SCHEMBL3665409 | 0.82 | MAPT (0.38) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11526201 | 0.82 | TYK2 (0.45) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11525111 | 0.81 | ATM (0.39) | RAB9ANPC1MAPTITGB1ITGA5 | |
| SCHEMBL11520972 | 0.80 | RAB9A (0.45) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11522082 | 0.79 | TYK2 (0.40) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11522591 | 0.77 | MAPT (0.39) | TYK2JAK2JAK1RAB9AMAPT | |
| SCHEMBL11372439 | 0.76 | ALDH1A1 (0.43) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL11523035 | 0.76 | MAPT (0.37) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11522193 | 0.75 | TYK2 (0.37) | TYK2JAK2JAK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |