Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DGKA | P23743 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11523885 | 1.00 | POLB (0.42) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11526294 | 1.00 | POLB (0.42) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11523888 | 1.00 | POLB (0.42) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11511502 | 0.99 | TRPA1 (0.41) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11511498 | 0.99 | TRPA1 (0.41) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11529324 | 0.94 | TRPA1 (0.35) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11529331 | 0.94 | TRPA1 (0.35) | POLBPOLA1TRPA1PPARGPPARA | |
| SCHEMBL11527732 | 0.89 | MAPK1 (0.32) | — | |
| SCHEMBL11527735 | 0.89 | MAPK1 (0.32) | — | |
| SCHEMBL11526961 | 0.86 | POLB (0.48) | POLBPOLA1TRPA1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161608-A | 11 Hydroxy methyl 11-deoxyprostaglandin E1 | AYERST, MCKENNA AND HARRISON LIMITED (CA) | 1979-07-17 | — | — | US | disclosed |
| US-4100343-A | 11-Deoxyprostaglandin derivatives | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1978-07-11 | — | — | US | disclosed |
| US-4089898-A | 11-Deoxyprostaglandin derivatives | AYERST, MCKENNA & HARRISON LTD. (CA) | 1978-05-16 | — | — | US | disclosed |
| US-4036856-A | PROSTAGLANDINS | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-07-19 | — | — | US | disclosed |
| US-4006136-A | Prostaglandin intermediates | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-02-01 | — | — | US | disclosed |