Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530550 | 0.89 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL11530824 | 0.81 | MEN1 (0.50) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| Dimethylformamide SCHEMBL11529329 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL9146128 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL5542522 | 0.77 | RAB9A (0.71) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL25215960 | 0.77 | PTGS1 (0.60) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL13154822 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL1512585 | 0.75 | MEN1 (0.62) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| Methylpyrrolidone SCHEMBL11528521 | 0.73 | BRD4 (0.49) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL22649378 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4178280-A | Stabilized polyolefin composition | R. T. VANDERBILT COMPANY, INC. (US) | 1979-12-11 | — | — | US | claimed |
| US-4178280-A | Stabilized polyolefin composition | R. T. VANDERBILT COMPANY, INC. (US) | 1979-12-11 | — | — | US | disclosed |