Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11533130 | 0.86 | MEN1 (0.52) | CHRM1HRH1NOS3NOS1NOS2 | |
| SCHEMBL11531571 | 0.83 | CHRM1 (0.52) | CHRM1HRH1PAK1MAPTMAPK1 | |
| SCHEMBL11533744 | 0.80 | CHRM1 (0.55) | CHRM1HRH1PAK1 | |
| SCHEMBL11526082 | 0.79 | CHRM1 (0.53) | CHRM1HRH1PAK1 | |
| SCHEMBL11530525 | 0.77 | DRD2 (0.51) | CHRM1HRH1PAK1 | |
| SCHEMBL5477914 | 0.71 | DRD2 (0.67) | CHRM1HRH1MAPTMAPK1LMNA | |
| SCHEMBL11532012 | 0.70 | CHRM1 (0.66) | CHRM1HRH1PAK1MAPTMAPK1 | |
| SCHEMBL11530539 | 0.69 | CHRM1 (0.62) | CHRM1HRH1PAK1 | |
| SCHEMBL11536340 | 0.69 | CHRM1 (0.56) | CHRM1HRH1PAK1MAPTKDM4E | |
| SCHEMBL2036762 | 0.69 | DRD2 (0.67) | CHRM1HRH1MAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |