Pyroxamine

Pyroxamine

SCHEMBL1152817

CN1CCC(OC(c2ccccc2)c2ccc(Cl)cc2)C1

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 3/20 0.68
CYP2D6 P10635 2/20 0.68
SLC6A3 Q01959 2/20 0.68
CHRM2 P08172 1/20 0.68
HTR1A P08908 1/20 0.68
ADRA2A P08913 1/20 0.68
CHRM1 P11229 1/20 0.68
DRD1 P21728 1/20 0.68
SLC6A2 P23975 1/20 0.68
ADRA1A P35348 1/20 0.68
OPRM1 P35372 1/20 0.68
KCNH2 Q12809 1/20 0.68
HRH3 Q9Y5N1 1/20 0.68
MAPK1 P28482 1/20 0.67
MEN1 O00255 2/20 0.65
MAPT P10636 2/20 0.65
KMT2A Q03164 2/20 0.65
TP53 P04637 1/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyroxamine SCHEMBL636692 0.91 DRD3 (0.56) DRD3CYP2D6SLC6A3CHRM2HTR1A
SCHEMBL2056216 0.85 DRD3 (0.71) DRD3CYP2D6SLC6A3CHRM2HTR1A
Hydrochloric Acid SCHEMBL1151732 0.83 MEN1 (0.60) DRD3CYP2D6SLC6A3CHRM2HTR1A
Diphenylpyraline SCHEMBL119077 0.82 DRD3 (1.00) DRD3CYP2D6SLC6A3CHRM2HTR1A
Hydrochloric Acid SCHEMBL1151739 0.82 MEN1 (0.58) DRD3CYP2D6SLC6A3CHRM2HTR1A
Hydrochloric Acid SCHEMBL1151799 0.82 MEN1 (0.58) DRD3CYP2D6SLC6A3CHRM2HTR1A
SCHEMBL1151611 0.81 DRD3 (0.56) DRD3CYP2D6SLC6A3CHRM2HTR1A
Diphenylpyraline SCHEMBL212198 0.81 MAPK1 (1.00) DRD3CYP2D6SLC6A3CHRM2HTR1A
Hydrochloric Acid SCHEMBL1152504 0.80 MEN1 (0.56) DRD3CYP2D6SLC6A3CHRM2HTR1A
Diphenylpyraline SCHEMBL4543024 0.79 DRD3 (0.93) DRD3CYP2D6SLC6A3CHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109415693-A Generation of human pluripotent stem cell-derived functional β cells showing glucose-dependent mitochondrial respiration and biphasic insulin secretion response 詹森生物科技公司 2019-03-01 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20250213629-A1 THERAPEUTIC PHARMACEUTICAL COMPOSITIONS SIOLTA THERAPEUTICS, INC. 2025-07-03 US disclosed
US-20240173368-A1 THERAPEUTIC PHARMACEUTICAL COMPOSITIONS SIOLTA THERAPEUTICS INC (US) 2024-05-30 US disclosed
US-11806373-B2 Therapeutic pharmaceutical compositions SIOLTA THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
US-20220362313-A1 THERAPEUTIC PHARMACEUTICAL COMPOSITIONS SIOLTA THERAPEUTICS, INC. 2022-11-17 US disclosed
CN-115135628-A Compounds for fast and efficient click release 泰克沃尔科斯制药有限公司 2022-09-30 CN disclosed
EP-4041264-A1 THERAPEUTIC PHARMACEUTICAL COMPOSITIONS Siolta Therapeutics, Inc. (US) 2022-08-17 EP disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 DRD3 4723/4885CYP2D6 4855/4885SLC6A3 2768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.