Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylpyraline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | DRD1 | P21728 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.97 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylpyraline SCHEMBL119077 | 0.98 | DRD3 (1.00) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| Diphenylpyraline SCHEMBL4543024 | 0.95 | DRD3 (0.93) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| Hydrochloric Acid SCHEMBL9357212 | 0.91 | MAPK1 (0.83) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| SCHEMBL9673190 | 0.89 | CHRM1 (0.82) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| Hydrochloric Acid SCHEMBL9357058 | 0.89 | MAPK1 (0.78) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| Hydrochloric Acid SCHEMBL9353118 | 0.86 | MAPK1 (0.74) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| SCHEMBL18469978 | 0.83 | CHRM1 (0.73) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| SCHEMBL2056216 | 0.81 | DRD3 (0.71) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| Maleic Acid SCHEMBL9353012 | 0.81 | SLC6A3 (0.68) | MAPK1DRD3SLC6A2CYP2D6CHRM2 | |
| SCHEMBL14282902 | 0.81 | DRD3 (0.69) | MAPK1DRD3SLC6A2CYP2D6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1481 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215956-A1 | LOW-TEMPERATURE METHOD OF PRODUCING MODIFIED RUBBER CRUMB | Vorobev Andrei Leonidovich (RU) | 2021-10-28 | — | — | WO | claimed |
| EP-3313183-B1 | AN AQUEOUS ANTIMICROBIAL FILM-FORMING COMPOSITION FOR TEAT TREATMENT BY SPRAY APPLICATION | ECOLAB USA INC (US) | 2020-07-08 | — | — | EP | claimed |
| EP-3565532-A1 | ORAL DISPERSIBLE FILM COMPOSITION | Bonayo Lifesciences Private Limited (IN) | 2019-11-13 | — | — | EP | claimed |
| US-20190336453-A1 | ORAL DISPERSIBLE FILM COMPOSITION | BonAyu Lifesciences Private Limited (IN) | 2019-11-07 | — | — | US | claimed |
| WO-2018127938-A1 | ORAL DISPERSIBLE FILM COMPOSITION | JUBELN LIFESCIENCES PVT. LTD. (IN) | 2018-07-12 | — | — | WO | claimed |
| US-9757376-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2017-09-12 | — | — | US | claimed |
| EP-2431028-B1 | FAST-DISSOLVING ORAL FILM FOR EFFECTIVELY CONCEALING UNPLEASANT TASTES | CHABIO & DIOSTECH CO LTD (KR) | 2017-07-12 | — | — | EP | claimed |
| US-20170112829-A1 | USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-04-27 | — | — | US | claimed |
| US-9561182-B2 | Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals | CURE PHARMACEUTICAL CORPORATION (US) | 2017-02-07 | — | — | US | claimed |
| US-9492379-B2 | Quickly soluble oral film dosage containing steviosides as a unpleasant taste masking agent | CHABIO & DIOSTECH CO., LTD. (KR) | 2016-11-15 | — | — | US | claimed |
| EP-1267829-A1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING AN ION EXCHANGE RESIN AS A TASTE MASKING AGENT | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | claimed |
| EP-1202721-A1 | CYCLOBENZAPRINE FOR TREATING GENERALIZED ANXIETY DISORDER AND COMPOSITIONS THEREOF | Vela Pharmaceuticals Inc. (US) | 2002-05-08 | — | — | EP | claimed |
| US-6358944-B1 | ADMINISTERING CYCLOBENZAPRINE OR METABOLITE; SIDE EFFECT REDUCTION | VELA PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | claimed |
| CN-1321080-A | Fast dissolving orally consumable films | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | CN | claimed |
| WO-2001070194-A1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING AN ION EXCHANGE RESIN AS A TASTE MASKING AGENT | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| US-20010022964-A1 | Fast dissolving orally consumable films | JOHNSON & JOHNSON CONSUMER INC. | 2001-09-20 | — | — | US | claimed |
| WO-2001012174-A1 | CYCLOBENZAPRINE FOR TREATING GENERALIZED ANXIETY DISORDER AND COMPOSITIONS THEREOF | VELA PHARMACEUTICALS INC. (US) | 2001-02-22 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |