SCHEMBL11528309

SCHEMBL11528309

CC1(C)CC(O[Si](C)(C)C)CC(C)(C)N1CCOC(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
SCN1A P35498 1/20 0.41
SCN2A Q99250 1/20 0.41
SCN3A Q9NY46 1/20 0.41
GAA P10253 2/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA5 P30532 1/20 0.40
CHRNA7 P36544 1/20 0.40
CHRNA4 P43681 1/20 0.40
NPC1 O15118 1/20 0.40
BCHE P06276 2/20 0.39
ATM Q13315 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11338831 0.86 TSHR (0.60) TSHRKMT2ALMNASMN1; SMN2TDP1
SCHEMBL11526038 0.79 SLC18A3 (0.35) ALDH1A1
SCHEMBL11203378 0.79 LMNA (0.42) TSHRKMT2ALMNASMN1; SMN2TDP1
SCHEMBL11499672 0.78 LMNA (0.51) TSHRKMT2ALMNASMN1; SMN2TDP1
SCHEMBL11813227 0.78 LMNA (0.51) TSHRKMT2ALMNASMN1; SMN2TDP1
SCHEMBL11741943 0.77 LMNA (0.50) TSHRKMT2ALMNASMN1; SMN2TDP1
SCHEMBL7857242 0.77 TSHR (0.67) TSHRKMT2ALMNATDP1SCN1A
SCHEMBL11545073 0.75 TSHR (0.55) TSHRKMT2ALMNASMN1; SMN2SCN1A
SCHEMBL11528307 0.75 TSHR (0.45) TSHRKMT2ALMNASMN1; SMN2SCN1A
SCHEMBL11541893 0.74 TSHR (0.51) TSHRKMT2ASMN1; SMN2SCN1ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4177186-A 4-SILOXY-DERIVATIVES OF STERICALLY HINDERED PIPERIDINES CIBA-GEIGY CORPORATION (US) 1979-12-04 US disclosed