Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11528309 | 0.75 | TSHR (0.44) | TSHRKMT2AGAANPC1CHRNA7 | |
| SCHEMBL27693321 | 0.74 | TSHR (0.65) | TSHRKMT2AGAAHTR3EHTR3B | |
| SCHEMBL10525245 | 0.73 | TSHR (0.64) | TSHRKMT2AGAAHTR3EHTR3B | |
| SCHEMBL51072 | 0.69 | TSHR (0.70) | TSHRKMT2AGAAPOLBHTR3E | |
| SCHEMBL9927137 | 0.67 | TSHR (0.70) | TSHRKMT2AGAAHTR3EHTR3B | |
| SCHEMBL243559 | 0.66 | TSHR (0.70) | TSHRKMT2AGAAPOLBHTR3E | |
| SCHEMBL294975 | 0.66 | TSHR (0.70) | TSHRKMT2AGAAHTR3EHTR3B | |
| SCHEMBL11526004 | 0.66 | CYP2D6 (0.36) | TSHRKMT2ALMNACYP2D6 | |
| SCHEMBL19720352 | 0.65 | TSHR (0.68) | TSHRKMT2AGAAPOLBHTR3E | |
| SCHEMBL11638418 | 0.65 | POLB (0.47) | TSHRKMT2ATP53POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177186-A | 4-SILOXY-DERIVATIVES OF STERICALLY HINDERED PIPERIDINES | CIBA-GEIGY CORPORATION (US) | 1979-12-04 | — | — | US | disclosed |