SCHEMBL11528538

SCHEMBL11528538

CC(C)CC(C)Nc1ccc(OCC(C)(C)COc2ccc(NC(C)CC(C)C)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
MAPK1 P28482 4/20 0.50
TSHR P16473 3/20 0.50
CYP3A4 P08684 3/20 0.50
ALOX15 P16050 2/20 0.50
HIF1A Q16665 2/20 0.50
HSD17B10 Q99714 2/20 0.50
ALOX12 P18054 1/20 0.50
L3MBTL1 Q9Y468 3/20 0.40
TDP1 Q9NUW8 3/20 0.40
TP53 P04637 1/20 0.40
HSP90AA1 P07900 1/20 0.40
THRB P10828 1/20 0.40
CASP1 P29466 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
EPHX2 P34913 1/20 0.39
CACNA2D1 P54289 1/20 0.36
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
MAPT P10636 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11526919 0.85 ALDH1A1 (0.60) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL11527652 0.83 TDP1 (0.42) ALDH1A1TSHRCYP3A4ALOX15HIF1A
SCHEMBL11529799 0.83 ALDH1A1 (0.56) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL11527693 0.81 ALDH1A1 (0.54) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL14813058 0.81 ALDH1A1 (0.54) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL11529802 0.81 MAPK1 (0.54) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL11527010 0.80 ALDH1A1 (0.53) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL144947 0.78 ALDH1A1 (0.73) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL11527791 0.78 ALDH1A1 (0.58) ALDH1A1MAPK1TSHRCYP3A4ALOX15
SCHEMBL25411983 0.73 ALDH1A1 (0.67) ALDH1A1MAPK1TSHRCYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4161474-A STABILIZERS, ANTIOZONANTS FOR VULCANIZABLE DIENE RUBBERS MONSANTO COMPANY (US) 1979-07-17 US disclosed