SCHEMBL11529366

SCHEMBL11529366

O=C=Nc1ccc(SC(F)(F)C(F)F)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
CYP3A4 P08684 2/20 0.34
TRPA1 O75762 1/20 0.34
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11079871 0.85 MAPK1 (0.56) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL2789021 0.85 MAPK1 (0.56) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11534389 0.84 MAPK1 (0.54) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11533832 0.83 MAPK1 (0.36) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11091500 0.80 MAPK1 (0.58) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11014346 0.80 MAPK1 (0.46) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11529569 0.79 MAPK1 (0.56) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL11531112 0.78 MAPK1 (0.54) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL10930709 0.75 MAPK1 (0.51) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL8715405 0.75 CYP3A4 (0.40) MAPK1TDP1CYP3A4TRPA1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140792-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1979-02-20 US disclosed