Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11529446 | 0.86 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL5578127 | 0.84 | KDM4E (0.47) | SMN1; SMN2NPC1RAB9AKMT2ATSHR | |
| SCHEMBL11527512 | 0.83 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL3400596 | 0.83 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11529880 | 0.83 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11529442 | 0.82 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11529156 | 0.81 | RAB9A (0.45) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11529222 | 0.80 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11530272 | 0.79 | POLB (0.49) | SMN1; SMN2NPC1RAB9AKMT2APOLB | |
| SCHEMBL11526544 | 0.79 | KDM4E (0.46) | SMN1; SMN2NPC1RAB9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288652-B2 | Reacting methyl 2-methyl-3-(pyrazin-2-yl)-3-oxopropionate with phosphorus pentasulfide in presence of mixed solvent of toluene andxylene under reflux to produce an oltipraz crude crystal; recrystallization; sulfiding, cyclization | CJ CORPORATION (KR) | 2007-10-30 | — | — | US | disclosed |
| US-7288652-B2 | Reacting methyl 2-methyl-3-(pyrazin-2-yl)-3-oxopropionate with phosphorus pentasulfide in presence of mixed solvent of toluene andxylene under reflux to produce an oltipraz crude crystal; recrystallization; sulfiding, cyclization | CJ CORPORATION (KR) | 2007-10-30 | — | — | US | disclosed |
| US-4144339-A | TREATMENT OF BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1979-03-13 | — | — | US | disclosed |
| US-4138487-A | NEMATOCIDES | RHONE-POULENC INDUSTRIES (FR) | 1979-02-06 | — | — | US | disclosed |
| US-4110450-A | BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1978-08-29 | — | — | US | disclosed |