SCHEMBL11530571

SCHEMBL11530571

CCOC(=O)c1cc(CC)sc1Nc1ccc(C(F)F)cc1[N+](=O)[O-]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.54
MAPT P10636 5/20 0.51
KDM4E B2RXH2 5/20 0.51
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 2/20 0.51
KMT2A Q03164 3/20 0.47
NPSR1 Q6W5P4 2/20 0.47
GAA P10253 3/20 0.47
POLB P06746 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HIF1A Q16665 1/20 0.47
ALOX12 P18054 1/20 0.46
HPGD P15428 5/20 0.46
LMNA P02545 4/20 0.46
TSHR P16473 1/20 0.46
MEN1 O00255 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
GALR2 O43603 1/20 0.44
MITF O75030 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11530416 0.89 ALDH1A1 (0.50) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11535384 0.86 ALDH1A1 (0.56) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11533991 0.85 ALDH1A1 (0.50) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11530538 0.85 ALDH1A1 (0.50) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11537764 0.85 HTT (0.51) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11531670 0.84 MAPT (0.54) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11532063 0.83 ALDH1A1 (0.49) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11530613 0.83 MAPT (0.51) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11532438 0.81 ALDH1A1 (0.52) ALDH1A1MAPTKDM4ECYP3A4CYP2C9
SCHEMBL11537678 0.81 ALDH1A1 (0.54) ALDH1A1MAPTKDM4ECYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4172831-A CENTRAL NERVOUS SYSTEM LILLY INDUSTRIES LIMITED (GB) 1979-10-30 US disclosed
US-4115574-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4115568-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed