Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530416 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11530538 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL11532962 | 0.89 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11533991 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11531670 | 0.87 | MAPT (0.54) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11532063 | 0.87 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11530571 | 0.86 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL11537764 | 0.86 | HTT (0.51) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11530613 | 0.84 | MAPT (0.51) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL11537678 | 0.84 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |