Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023735 | 0.81 | BRD4 (0.46) | BRD4CYP1A2HIF1ASLC6A2SLC6A4 | |
| SCHEMBL1613761 | 0.80 | MAPT (0.65) | MAPTALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL12714321 | 0.78 | MAPT (0.34) | BRD4MAPTALDH1A1 | |
| SCHEMBL11529096 | 0.75 | ALDH1A1 (0.68) | BRD4MAPTALDH1A1CHRM2CHRM4 | |
| SCHEMBL31297458 | 0.74 | MAPT (0.47) | BRD4MAPTALDH1A1CYP1A2HIF1A | |
| SCHEMBL11492920 | 0.72 | FKBP1A (0.48) | BRD4ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL12363788 | 0.70 | NOTUM (0.44) | BRD4SLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL3201971 | 0.70 | BRD4 (0.39) | BRD4ALDH1A1CYP1A2HIF1AMMP2 | |
| SCHEMBL3105740 | 0.69 | BRD4 (0.44) | BRD4CYP1A2HIF1ASLC6A2SLC6A4 | |
| SCHEMBL11756557 | 0.69 | BRD4 (0.38) | BRD4ALDH1A1CYP1A2HIF1AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4153711-A | 3-(3H-Pyrazol-3-one)-2-(disubstituted aminomethyl)indoles and pharmaceutical preparations | WARNER-LAMBERT COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4140858-A | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production | WARNER-LAMBERT COMPANY (US) | 1979-02-20 | — | — | US | disclosed |
| US-4132792-A | Bis(2-[(disubstituted amino)methyl]-1H-indole) compounds | WARNER-LAMBERT (US) | 1979-01-02 | — | — | US | disclosed |