Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 11/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11635638 | 0.93 | HRH4 (0.62) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11634626 | 0.86 | DRD2 (0.51) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11629466 | 0.84 | DRD2 (0.55) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11635569 | 0.84 | DRD2 (0.53) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11531378 | 0.83 | DRD2 (0.74) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11536095 | 0.82 | MEN1 (0.55) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11532513 | 0.80 | HRH4 (0.49) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11631861 | 0.80 | DRD2 (0.55) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11635201 | 0.80 | DRD2 (0.54) | HRH4DRD2DRD4CHRM1CHRM2 | |
| SCHEMBL11631525 | 0.80 | HRH4 (0.74) | HRH4DRD2DRD4CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |