Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.46 |
| ▸ | DRD1 | P21728 | 6/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 5/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.46 |
| ▸ | HTR2B | P41595 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11535575 | 0.88 | DRD2 (0.60) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11631861 | 0.87 | DRD2 (0.55) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11531378 | 0.87 | DRD2 (0.74) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11629466 | 0.84 | DRD2 (0.55) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11635638 | 0.82 | HRH4 (0.62) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11536095 | 0.82 | MEN1 (0.55) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11533334 | 0.80 | HRH4 (0.54) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11635569 | 0.79 | DRD2 (0.53) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11634626 | 0.78 | DRD2 (0.51) | DRD2DRD4CHRM1DRD3CHRM2 | |
| SCHEMBL11533102 | 0.78 | KMT2A (0.57) | DRD2DRD4CHRM1DRD3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | disclosed |