Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11533835 | 0.86 | LMNA (0.40) | MAPK1KMT2AMEN1EPAS1GAA | |
| SCHEMBL11528799 | 0.83 | AKR1C3 (0.47) | MAPK1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL25101501 | 0.82 | LMNA (0.47) | MAPK1KMT2AMEN1EPAS1GAA | |
| SCHEMBL11531797 | 0.82 | LMNA (0.39) | MAPK1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4835505 | 0.80 | LMNA (0.40) | MAPK1KMT2AMEN1GAAMAPT | |
| SCHEMBL11537764 | 0.78 | HTT (0.51) | MAPK1KMT2AMEN1GAAMAPT | |
| SCHEMBL4839033 | 0.73 | MAPK1 (0.47) | MAPK1KMT2AMEN1EPAS1GAA | |
| SCHEMBL7272347 | 0.72 | MAPK1 (0.52) | MAPK1KMT2AMEN1EPAS1GAA | |
| SCHEMBL4842658 | 0.72 | EPAS1 (0.53) | MAPK1KMT2AMEN1EPAS1GAA | |
| SCHEMBL6141228 | 0.72 | MAPK1 (0.70) | MAPK1KMT2AMEN1EPAS1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |